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5-Fluorouracil (5-FU, Efudix)

A topical anti-cancer medication (pyrimidine analog antimetabolite). Used at 0.5–5% for actinic keratoses and superficial skin cancers.

Category/Notes

Chemotherapeutic (keratolytic)

Benefits

Destroys precancerous and cancerous cells: 5-FU selectively targets rapidly dividing atypical cells in the skin. When applied to areas with sun damage, it causes a reaction that erodes actinic keratoses and superficial basal or squamous cell carcinomas. Over a few weeks of use, lesions crust and flake off, replaced by new healthy skin. Post-treatment, clinical studies show smoother, younger-looking skin due to the removal of dysplastic cells and sun-damaged collagen. It’s a gold-standard field therapy for sun-induced skin damage (with the side effect of temporary redness and irritation during treatment).

The Science Behind

5-Fluorouracil (5-FU, Efudix)