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The Science of ProXylane®: Supporting Your Skin from Within

Some ingredients promise quick fixes. Others go deeper — quietly rebuilding what time and stress take away. ProXylane®is one of those rare ingredients that doesn’t just sit on the surface, but works with your skin to restore its own strength, hydration, and resilience over time.

Originally developed by L’Oréal, this molecule has become a trusted ally in advanced skincare — not because it’s trendy, but because it’s proven.

What Is ProXylane®?

ProXylane® is a lab-designed molecule that helps your skin do what it was made to do: stay strong, supple, and hydrated. It encourages your skin to produce glycosaminoglycans (GAGs) — natural compounds that act like moisture magnets, keeping skin plump and comfortable.

Rather than offering a temporary surface effect, ProXylane® supports the deeper layers of your skin, where real regeneration begins.

How It Works

🧬 Supports natural hydration
By boosting your skin’s own ability to create hyaluronic acid and other moisture-retaining elements, ProXylane® helps maintain hydration from the inside out.

🏗️ Strengthens skin structure
It also helps reinforce the connection between the dermis (your skin’s deeper layer) and the epidermis (the surface). This connection is vital for firmness, elasticity, and that healthy, lifted appearance

Why It Matters

✨ Hydration that lasts
Think of GAGs as natural sponges in your skin. ProXylane® increases their presence, allowing skin to hold onto water longer — without relying on heavy creams.

💪 Firmness from within
With stronger support between skin layers, your complexion can appear more resilient, even, and firm — not temporarily, but with long-term consistency.

🤝 Works well with hyaluronic acid
In clinical studies, ProXylane® combined with hyaluronic acid showed improved hydration, reduced water loss, and even enhanced your skin’s own production of hyaluronic acid. It’s a pairing that amplifies both comfort and results.

A Thoughtful Ingredient for Modern Skincare - At Gentlelab, we believe skincare should feel like self-respect — calm, effective, and made with intention. That’s why we choose ingredients like ProXylane®: not for the hype, but for the way it gently supports your skin’s natural function.

Sources

Eun, H. C., & Lee, A. Y. (1985). Contact dermatitis due to Madecassol. Contact Dermatitis, 13(5), 310–313. https://doi.org/10.1111/j.1600-0536.1985.tb02584.x

Haftek, M., MacMary, S., Bitoux, M. L., Creidi, P., Seité, S., Rougier, A., & Humbert, P. (2008). Clinical, biometric and structural evaluation of the longterm effects of a topical treatment with ascorbic acid and madecassoside in photoaged human skin. Experimental Dermatology, 17(11), 946–952. https://doi.org/10.1111/j.1600-0625.2008.00732.x

Kongkaew, C., Meesomperm, P., Scholfield, C. N., Chaiwiang, N., & Waranuch, N. (2020). Efficacy and Safety of Centella Asiatica (L.) Urb. on Wrinkles: A Systematic Review of Published Data and Network Meta-Analysis. Journal of cosmetic science, 71(6), 439–454.

Lee, Y., Choi, H. K., N’deh, K. P. U., Choi, Y., Fan, M., Kim, E., Chung, K., & An, J. H. (2020). Inhibitory Effect of Centella asiatica Extract on DNCB-Induced Atopic Dermatitis in HaCaT Cells and BALB/c Mice. Nutrients, 12(2), 411. https://doi.org/10.3390/nu12020411

Lin, P., Shi, H., Lu, Y., & Lin, J. (2023). Centella asiatica alleviates psoriasis through JAK/STAT3-mediated inflammation: An in vitro and in vivo study. Journal of Ethnopharmacology, 317, 116746. https://doi.org/10.1016/j.jep.2023.116746

Milani, M., & Sparavigna, A. (2017). The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and <em>Centella asiatica</em> stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study. Clinical Cosmetic and Investigational Dermatology, Volume 10, 311–315. https://doi.org/10.2147/ccid.s144180

Seo, J., Jeong, C., Oh, S., Lee, S., Park, H., Seo, D., Yoo, D., Sim, W., Lim, T., Park, J. H. Y., Lee, C., & Lee, K. (2024). Giant Centella asiatica, a novel cultivar rich in madecassoside and asiaticoside, suppresses α melanocyte stimulating hormone induced melanogenesis through MC1R binding. International Journal of Molecular Medicine, 55(1). https://doi.org/10.3892/ijmm.2024.5454

The Science Behind

The Science of ProXylane®: Supporting Your Skin from Within